Endocrine Abstracts

Aim: The aim of our study was to investigate is surgical stress induce alterations in insulin sensitivity in the course of cholecystectomy performed in two differnt procedures: as a open surgery and as laparascopic operation.Material and methods: The homeostasis assessment model (HOMA) was used to determine insulin sensitivity before and in the first, third and seventh day after the operation. Patients were divided int two groups: group A (open cholecyst...

Aim: To calculate mean HbA1c values in patients with type 2 diabetes mellitus in different therapy regiments.Material and methods: Ninety-nine diabetic persons was divided in three groups: group I (n=33) on oral hypoglucemic agents, group II (n=33) on one or two doses of insulin and group III (n=33) on intensive insulin therapy. We have calculated the mean values of HbA1c on the begining and 6 months after start of therapy regiment.<...

Aim/hypothesis: Chronic renal failure maintenance hemodialysis (HD) patients are at risk for low bone mineral density (BMD) and fractures. Parathyroid hormone (iPTH) plays a pivotal role in the pathophysiology of uremic bone disease, but in healthy population body weight and particularly body composition are more important determinants of bone mass.Patients and methods: We studied BMD (results were recorded as g/cm2) and T score using D...

Objective: Hot flushes and night sweats experienced by 60–70% of postmenopausal women are considered as classical signs of menopause. Estrogens is the gold standard treatment, but in view of its potential risks, various herbal preparations and vitamin supplements have a great appeal to women. Aim of this study was to assess the effect of a nutritional supplement (Menopace®) on the frequency and severity of hot flushes and the quality of life in postmenopausal women i...

Background: Adult hypopituitarism is associated with premature vascular mortality for which the underlying mechanisms are unknown but untreated GH deficiency is proposed as a potential contributor.Objectives: To characterise vascular risk, including paraoxonase-1 (PON1; an antioxidant enzyme which preserves LDL against oxidation), in adults with treated panhypopituitarism.Study subjects: The study had full ethics approval. Data are...

This investigation used primary cultured rat vascular smooth muscle cells (VSMCs) to examine the effects of insulin (INS) on proliferation of VSMCs. In this study, protein kinase B (Akt) and p42/44 mitogen-activated protein kinase (ERK 1/2) signaling pathways in mediating the mitogenic actions of INS in VSMCs was investigated. Incubation of a rat VSMCs with INS (100 nM) for 10 min resulted in an increase of Akt phosphorylation by 6-fold (P<0.001) and ERK 1/2 phospho...

Background: Adult hypopituitarism is associated with premature vascular mortality for which the underlying mechanisms are unknown but untreated GH deficiency is proposed as a potential contributor.Objectives: To characterise vascular risk, including paraoxonase-1 (PON1; an antioxidant enzyme which preserves LDL against oxidation), in adults with treated panhypopituitarism.Study subjects: The study had full ethics approval. Data are...

Background/Aims: High level of inflammatory cytokines was present within malnourished and chronic renal failure maintenance hemodialysis (MHD) patients, but there were conflicting data about the role of inflammation on development of insulin resistance (IR) in non-obese and overweight MHD patients.Methods: We selected 23 well-nourished and 20 middle- to moderate-malnourished, sex and age-matched, stable MHD patients, 23 male and 20 female, with median di...

Introduction: Acromegaly is a chronic disease that occurs as a result of excessive growth hormone secretion, caused by somatotropin-secreting tumors of the pituitary gland in 98% of cases. The first line of treatment for these patients is operative via transsphenoidal approach, however, absolute remission is not achieved in 50% of patients and pharmacological therapy is indicated.Case report: We will present the case of a 43-year-old patient who was hosp...

Objective: Focal adhesion kinase (FAK) is non-receptor tyrosine kinase that has been shown to affect cell motility, adhesion, invasion, cell survival, proliferation and de-differentiation. Its increased expression has been reported for various types of malignancies and is associated with cancer progression. However, there are less information regarding its posttranslational form, phosphorylated at Tyrosine 397 (pY397-FAK), which represents a key event for complete protein acti...